The foundation stone of the College of Agricultural Biotechnology, Latur was laid in the year in 2006 (vide MH G.R. No. MKV 1005/PK299/7A dated 5th July, 2006) towards the education, research and extension in the area of Agricultural Biotechnology and related technology with view towards welfare of the farmers and students, who get well-acquainted with the biotechnological tools and techniques during their four years of B.Sc.(Agril. Biotechnology) degree programme. The college was started with an intake capacity of 32 students and it is increased to 40 students from the academic year 2010-11. Furthermore, the intake capacity increased to 50 as per ICAR norms from academic year 2022-23. This college was re-named as ‘Vilasrao Deshmukh College of Agricultural Biotechnology, Latur’ in the memory of the visionary leader and former Chief Minister of Maharashtra Late Shri. Vilasraoji Deshmukh on dated 3rd September, 2013. Under the ICAR’s regime and as per the V Deans’ Committee recommendations, the degree programme has restructured into new curricula with degree nomenclature as ‘B.Tech. (Biotechnology)’ w.e.f. academic year 2017-18.

The Post Graduate programme in M.Sc. (Agricultural Biotechnology) was started in the year 2001 at VNMKV, Parbhani with financial support from DBT (GOI), New Delhi, subsequently the program was shifted to Latur from September, 2009 as the Faculty of Biotechnology was started at Latur campus in the year 2006. The master degree programme has also restructured into new curricula as per BSMA w.e.f. academic year 2022-23. The intake capacity for PG Programme is 38 students (30 students are admitted through all India entrance test conducted i.e. GAT-B by DBT, New Delhi and 8 students from the State CET conducted by MCAER, Pune).